Prof. MUDr. Sylvie Dusilová Sulková, DrSc.
Nefrologická klinika LF UK a FN Hradec Králové
Prof. MUDr. Sylvie Dusilová Sulková, DrSc., MBA, lékařka a vysokoškolská profesorka.
Vystudovala fakultu všeobecného lékařství (nyní 1. LFUK). Po promoci nastoupila na Interní oddělení Strahov (součást nynější Všeobecné fakultní nemocnice), tj. na pracoviště se zaměřením zejména na dialyzační léčbu selhání ledvin. V letech 1997-2004 působila ve funkci přednostky tohoto pracoviště. Od roku 2006 pracuje ve Fakultní nemocnici Hradec Králové (s výjimkou období 2010-2012, kdy byla vedoucí lékařkou klinického oddělení Kliniky Nefrologie IKEM, Praha), kde je vedoucí lékařkou oboru nefrologie. Od srpna 2012 byla vedoucí lékařkou Hemodialyzačního střediska (kam od od roku 2015 přiřazena i klinická a transplantační nefrologie) a od ledna 2022 je přednostkou nově ustanovené Nefrologické kliniky FNHK a LFUK v Hradci Králové.
Od roku 2006 vede časopis Aktuality v nefrologii; od téhož roku je členkou Vědecké rady LFUK v Hradci Králové, je členkou akreditační komise MZd pro obor nefrologie i členkou zkušebních komisí pro atestace v oboru nefrologie; vyučuje na lékařské fakultě, je členkou řady dalších odborných komisí.
Je dlouholetou členkou výboru České nefrologické společnosti, dvakrát byla zvolena předsedkyní společnosti.
Publikuje vědecké práce i odborné monografie, převážně se zaměřením na chronické onemocnění ledvin a jeho léčbu; specificky se věnuje mimo jiné problematice minerálové a kostní poruchy při nemocech ledvin; její H-index 18.
Volný čas věnuje knihám, přírodě, cestování, rodině a přátelům. Je podruhé vdaná, syn Štěpán je dětský psychiatr.
Prof. MUDr. Sylvie Dusilová Sulková, DrSc. je autorem těchto článků v časopise Postgraduální nefrologie:
Pereira LA, Meng C, Gonc MA, et al. Etelcalcetide controls secondary hyperparathyroidism and raises sclerostin levels in hemodialysis patients previously uncontrolled with cinacalcet. Nefrologia 2022, https://doi.org/10.1016/j.nefroe.2022.11.014
Vanholder R, Gallego D, Sever MS. Wars and kidney patients: a statement by the European Kidney Health Alliance related to the Russian‑Ukrainian conflict. J Nephrol 2022 Mar 5:1–4. doi: 10.1007/s40620‑022‑01301‑4. Online ahead of print.
Kim K, Song SH, Kim IJ, Jeon YK. Is dual‑energy absorptiometry accurate in the assessment of bone status of patients with chronic kidney disease? Osteoporosis Int 2021;32:1859–1868.
Greenberg KI, Choi MJ. Hemodialysis Emergencies: Core Curriculum 2021. Am J Kidney Dis 2021;77:796–807.
Voora S, Adey DB. Management of kidney transplant recipients by general nephrologists: Core Curriculum 2019. Am J Kidney Dis 2019;73:866–879.
Ureña‑Torres P, Vervloet M, Mazzaferro S, et al. Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease. Clin Kidney J 2019;12;269–280. The Parathyroid Day in Chronic Kidney Disease’ CME course Paris in September 2017.
Clin Kidney J 2018;11:599–604.
Brandenburg VM, Evenepoel P, Floege J, et al., on behalf of ERA‑EDTA Working Group on CKD‑MBD and EUCALNET.
Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis? Nephrol Dial
Transplant 2016;31:1211–1219.
Meyring‑Wosten A, Zhang H, Ye X, et al. Intradialytic hypoxemia and clinical outcomes in patients on hemodialysis. Clin J Am Soc Nephrol 2016; published on March 2; doi: 10.2215/CJN/08510815
Peters SAE, Bots ML, Canaud B, et al., on behalf of the HDF Pooling Project Investigators. Haemodiafiltration and mortality in end‑stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials. Nephrol Dial Transplant 2015 Oct 22; doi:10.1093/ndt/gfv349 V posledních letech
Weir MA, Dixon SN, Fleet JL. β‑blocker dialyzability and mortality in older patients receiving hemodialysis. J Am Soc Nephrol 2015;26:987–996.
Laville M, Dorval M, Ros JF, Fay R, Cridlig J, Nortier JL, Juillard L, Debska‑Slizien A, Lorente LF, Thibaudin D, Granssen C, Schulz M, Moureau F, Loughraieb M, Rossignol P. Results of the HepZero study comparing heparin‑grafted membrane and standard care show that heparin‑grafted dialyser is safe and easy to use for heparin‑free dialysis. Kidney Int 2014;86:1260–1267.
Robinson BM, Zhang J, Morgenstern H, et al. Worldwide, mortality risk is high soon after initiation of hemodialysis. Kidney Int 2014;85:158—165.
Eldehni MT, Odudu A, McIntyre CW. Randomized clinical trial of dialysate cooling and effects on brain white matter. J Am Soc Nephrol 2014. doi: 10.1681/ASN.2013101086
Vazquez E, Sanchez‑Perales C, Garcia‑Garcia F, et al. Sudden death in incident dialysis patients. Am J Nephrol 2014;39: 331–336.
Susantitaphong P, Siribamrungwonf M, Jaber B. Convective therapies versus low‑flux hemodialysis for chronic kidney failure: a meta‑analysis of randomized controlled trials. Nephrol Dial Transplant 2013; doi:10.1093/ndt/gft396
Jamal SA, Vandermeer B, Raggi P, et al. Effect of calcium‑based versus non‑calcium based phosphate
binders on mortality in patients with chronic kidney disease: an
updated systematic review and meta‑analysis. Lancet 2013. Doi:
org/10.1015/50140‑6736(13)60897‑1
Di Iorio B, Molony D, Bell C, et al: Sevelamer versus calcium carbonate in incident
hemodialysis patients: results of an open‑label 24‑month randomized
clinical trial. Am J Kidney Dis 2013. Doi:
org/10.1053/j.ajkd.2013.03.023
Hughes SA, Mendelssohn JG, Tobe SW, McFarlane FA, Mendelssohn DC. Factors associated with suboptimal initiation of dialysis despote early nephrologist referral. Nephrol Dial Transplant 2013;28:392–297.
Floege J, Raggi P, Block GA, et al. Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in hemodialysis patients. Nephrol Dial Transplant 2010;25:1916–1923.
Raggi P, Chertow GM, Urena‑Torres P, et al. The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low‑dose vitamin D on vascular calcification in patients on hemodialysis. Nephrol Dial Transplant 2010;26:1327–1339.
Urena‑Torres P, Floege J, Hawley CM, et al: Protocol adherence and the progression of cardiovascular calcification in the ADVANCE study. Nephrol Dial Transplant 2012, doi: 10.1093/ndt/gfs356
Harris TJ, Nazir R, Khetpal R, et al. Pain, sleep disturbances and survival in hemodialysis patients. Nephrol Dial Transplant 2012;27:758–765.
Yilmaz MI, Sonmez A, Saglam M, et al. Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients: a randomized clinical trial. Am J Kidney Dis 2012;59:177–185.
Westenfeld R, Schlieper G, Woltje M, et al. Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis – implications for post‑transplant bone disease. Nephrol Dial Transplant 2011;26:4115–4123.
Kovesdy CP, Molnár MZ, Czira ME, et al. Diagnostic accuracy of serum parathyroid hormone levels in kidney transplant recipients with moderate‑to‑advanced CKD. Nephron Clin Pract 2011;118:c78–c85.
Jouret F, et al. Positron‑emission computed tomography in cyst infection in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2011; 6:1644–1650.
Cejka D, Jager‑Lansky A, Kieweg H, et al. Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant 2011 May 25. [Epub ahead of print]
Cejka D, Herberth J, Branscum AJ, et al. Sclerostin and Dickkopf‑1 in renal osteodystrophy. Clin J Am Soc Nephrol 2011;6:877–882.
Nogueira EL, Costa AC, Santana A, Querna JO, Silva S, Mil‑Homens C, Costa AG. Teriparatide efficacy in the treatment of severe hypocalcemia after kidney transplantation in parathyreoidectomized patients: a series of five case reports. Transplantation 2011;92:316–320.
Farese S, Stauffer E, Kalicki R, et al. Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. Clin J Am Soc Nephrol 2011; 6:1447–1455.
Bernardo AP, Contesse SA, Bajo MA, Rodriques A, Del Peso G, Ossorio M, Cabrita A, Selgas R. Peritoneal membrane phosphate transport status: a cornerstone in phosphate handling in peritoneal dialysis. Clin J Am Soc Nephrol 2011; doi: 10.2215/CJN06960810
Floege J, Kim J, Ireland E, Chazot Ch, Drueke T, de Francisco A, Kronenberg F, Marcelli D, Paslick‑Deetjen J, Schrenthaner G, Fouqueray B, Wheeler D on behalf of ARO investigators: Serum iPTH, calcium and phosphate, and the risk of mortality in a European hemodialysis population. Nephrol Dial Transplant 2010; in print.
Block GA, Brillhart SL, Persky MS, Amer A, Slade AJ. Efficacy and safety of SBR759, a new iron-based phosphate binder. Kidney Int 2010;77:897–903.
Verdalles U, Abad S, Aragoncillo I, Millaverde M, Jofre R, Verde E, Vega A, Lopez-Gomez JM. Factors predicting mortality in elderly patients on dialysis. Nephron Clin Pract 2010;115:c28–c34.
Galitzer H, Ben-Dov IZ, Silver J, Naveh-Many T. Parathyroid cell resistence to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int 2010;77:211–218.
DeLoach S, Joffe MM, Mai X, et al. Aortic calcification predict cardiovascular events and all-cause mortality in renal transplantation. Nephrol Dial Transplant 2009;24:1314–1319.
Navaro‑Gonzalez J, Mora‑Fernandez C, Muros M, Herrera H, Garcia J. Mineral metabolism and inflammation in chronic kidney disease patients. Clin J Am Soc Nephrol 2009;4:1646–1654.
Evenepoel P, van den Bergh B, Naesens M, de Jonge H, Mammens B, Claes K, Kuypers D, Vanrenterghem Y. Calcium metabolism in the early posttransplantation period. Clin J Am Soc Nephrol 2009;4:665–672.
Navaneethan SD, Yehnert H, Moustarah F, Schreiber MJ, Schauer PR, BeddhuS. Weight loss interventions in chronic kidney disease: a systemic review and meta‑analysis. Clin J Am Soc Nephrol 2009; doi 10.2215/CJN.00250409.
Chan KE, Lazarus JM, Thadhani R, Hakim RM. Anticoagulant and antiplatelet usage associates with mortality among hemodialysis patients. J Am Soc Nephrol 2009;20:872–881.
Vazquez E, Sanchez‑Perales C, Garcia‑Garcia F, Castellano P, Garcia‑Cortes MJ, Liebana A, Lozeno C. Atrial fibrillation in incident dialysis patients. Kidney Int 2009;76:324–330.
Bradbury BD, Critchlow CW, Weir M et al. Impact of elevated C-reactive protein levels on erythropoiesis – stimulating agent (ESA) dose and responsiveness in hemodialysis patients. Nephrol Dial Transplant 2009;24:919–925.
Jean G, Bresson E, Errat JC, et al. Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. NephrolDial Transplant 2009;24:948–955.
Okša A, Spustová V, Krivošíková Z, Gazdíková K, Fedelešová V, Lajdová I, Štefíková K, Bernasovská G, Žilinská Z, Dzúrik R. Effects of long-term cholecalciferol supplementation on mineral metabolism and calciotropic hormones in chronic kidney disease. Kidney Blood Press Res 2008;31:322–329.
Gutierrez OM, Mannstadt M, Isakova T, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008; 359:584–592.
Panagua R, Amato D, Vonesh E, Guo A, Mujais S. Health-related quality of life predicts outcomes but is not affected by peritoneal clearance. The ADEMEX trial. Kidney Int 2005; 67:1093–1104.
Stenvinkel P, Wang K, Qureshi A, Axelson J, Pecoits-Filho R, Gao P, Barany P, Lindholm B, Hogestrand T, Heimburger O, Holmes C, Challing M, Nordfors L. : Low fetuin A levels are associated with cardiovascular death: impact of variations in the gene encoding fetuin. Kidney Int 2005;67:2383–2392.
Nakanishi S, Kazama J, Nii-Kono T, Omori K, Yamashita T, Fukumoto S, Gejyo F, Schigematsu T, Fugakawa M. Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyreoidism in dialysis patients. Kidney Int 2005;67:1171-1178.
Tarek ME, Ohmit SE, McCullough PA, Crook ED, Brown WW, Grimm R, Bakris GL, Keane W, Flack JM. Higher prevalence of anemia with diabetes mellitus in moderate kidney insufficiency. The Kidney Early Evaluation Program. Kidney Int 2005;67:1483-1488.
Moe S, Reslerova M, Ketteler M, et al. : Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int 2005;67:2295-2304.
Teng M, Wolf M, Ofsthun MN, Lazaru JM, Hernán MA, Camargo CA Jr, Thandhani R. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005;16:1115-1125.
Bommer J, Locatelli F, Satayathum S, Keen ML, Goodkin DA, Saito A, Akiba T, Port FK, Zouny EW. Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 2004;44:661-671.
Gouva Ch, Nikolopoulos P, Ioannidis PA, Siamopoulos KC. Treating anemia early in renal failure patients slows the decline of renal function: A randomized controlled trial. Kidney Int 2004;66:753–760.
Block A, Martin KJ, de Francisco ALM, Turner S, et al. Cinacalcet hydrochloride for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004;350:1516–1525.
Avesani CM, Draibe SA, Kamimura MA, Colugnati FAB, Cuppari L. Resting energy expenditure of chronic kidney disease patients. Influence of renal function and subclinical inflammation. Am J Kidney Dis 2004;44:1008–1016.
Young EW, Akiba T, Albert JM, McCarthy JT, Kerr PG, Mendelssohn DC, Jadoul M. Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 2004;44(Suppl 2):S34–S38.
Sanchez C, Lopez-Barea F, Sanchez-Cabezudo S, Bajo A, Mate A, Martinez E, Selgas R for the Collaborators of the Multicentre Study Group. Low vs standard calcium dialysate in peritoneal dialysis: differences in treatment, biochemistry and bone histomorphometdy. A randomized multicentre study. Nephrol Dial Transplant 2004;19:1587-1593.
Dember LM, Holmberg EF, Kaufman JS. Randomized controlled trial of prophylactic repair of hemodialysis arteriovenous graft stenosis. Kidney Int 2004;66:390-398.
Troidle L, Gorban.Brennan N, Kliger A, Finkelsterin FO: Continuous peritoneal dialysis-associated peritonitis: a review and current concepts. Semin Dial 2003;16:428-437.
Cunningham J, Sprague SM (on behalf of the Osteoporosis Work Ggroup): Osteoporosis in chronic kidney disease. Am J Kidney Diseases 2004;43: 556-571.
Zayour D, Daouk M, Medawar W, et al. Predictors of bone mineral density in patiens on hemodialysis. Transpl Proc 2004;36:1297-1301.